BiologicalNetworks database integrates over 100 curated and publicly contributed
data sources and provides functional, genetic, genomic, transcriptomic and proteomic information.
Information featured in the database includes gene function, pathways, protein-protein interactions, gene expression,
orthologies, mutations and SNPs, disease relationships, related drugs and compounds.
Representative organisms are:
- Budding Yeast (Saccharomices cerevisiae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fly (Drosophila melanogaster)
- Caenorhabditis elegans
- Arabidopsis thaliana
- Mouse (Mus musculis)
- Human (Homo sapiens)
- Zebrafish (Danio rerio)
Representative data sources are:
- MIPS data (http://mips.gsf.de/genre/proj/yeast/)
- KEGG (http://www.genome.ad.jp/kegg)
- Transfac (http://www.gene-regulation.com/)
- BIND database (http://bind.ca/)
- pre-BIND database (http://www.blueprint.org/products/prebind/)
- CSH data (http://rulai.cshl.edu/SCPD/)
- MIT transcriptional data (Lee, T. et al. (2002) "Transcriptional regulatory networks in Saccharomyces
cerevisiae". Science, 298, 799804.) http://web.wi.mit.edu/young/regulatory_network/
- UCSF localization data (Huh, W.K. et al. (2003), "Global analysis
of protein localization in budding yeast". Nature 425,686-91.)
- Co-immunoprecipitation data (Gavin, A. C. et al. (2002) "Functional
organization of the yeast proteome by systematic analysis of protein complexes".
Nature, 415, 141147.)
- Co-immunoprecipitation data (Ho, Y. et al. (2002) "Systematic identification
of protein complexes in saccharomyces cerevisiae by mass spectrometry".
Nature, 415, 180183.)
- Yeast-two hybrid data (Ito, T. et al. (2001) "A comprehensive two-hybrid
analysis to explore the yeast protein interactome". Proc Natl Acad
Sci U S A. 98, 4569-74 . )
- Yeast-two hybrid data (Uetz, P. et al. (2000) "A comprehensive analysis
of protein-protein interactions in Saccharomyces cerevisiae". Nature
403,623-7.)
- Genetic interaction data (Tong, A. H. Y. et al. (2001) "Systematic
genetic analysis with ordered arrays of yeast deletion mutants". Science,
294, 23642368.)
- Genetic interaction data (Tong, A.H. et al. "Global mapping of the
yeast genetic interaction network". Science 303, 808-13 (2004).)
